loratadine

Ligand id: 7216

Name: loratadine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 0
Rotatable bonds 3
Topological polar surface area 42.43
Molecular weight 382.14
XLogP 4.26
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Cuboni S, Devigny C, Hoogeland B, Strasser A, Pomplun S, Hauger B, Höfner G, Wanner KT, Eder M, Buschauer A et al.. (2014)
Loratadine and analogues: discovery and preliminary structure-activity relationship of inhibitors of the amino acid transporter B(0)AT2.
J. Med. Chem.57 (22): 9473-9. [PMID:25318072]
2. Janssens F, Leenaerts J, Diels G, De Boeck B, Megens A, Langlois X, van Rossem K, Beetens J, Borgers M. (2005)
Norpiperidine imidazoazepines as a new class of potent, selective, and nonsedative H1 antihistamines.
J. Med. Chem.48 (6): 2154-66. [PMID:15771458]