Synonyms: (1R,4S)-trans-norsertraline | SEP-225,289 | SEP-225289
Compound class:
Synthetic organic
Comment: Dasotraline is a triple reuptake inhibitor [1,3]. Such compounds are also known as serotonin-norepinephrine-dopamine reuptake inhibitors, or SNDRIs. Structurally, dasotraline is a stereoisomer of an active metabolite of sertraline, a selective serotonin reuptake inhibitor (SSRI) antidepressant.
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References |
1. Chen Z, Skolnick P. (2007)
Triple uptake inhibitors: therapeutic potential in depression and beyond. Expert Opin Investig Drugs, 16 (9): 1365-77. [PMID:17714023] |
2. DeLorenzo C, Lichenstein S, Schaefer K, Dunn J, Marshall R, Organisak L, Kharidia J, Robertson B, Mann JJ, Parsey RV. (2011)
SEP-225289 serotonin and dopamine transporter occupancy: a PET study. J Nucl Med, 52 (7): 1150-5. [PMID:21680689] |
3. Guiard BP, Chenu F, El Mansari M, Blier P. (2011)
Characterization of the electrophysiological properties of triple reuptake inhibitors on monoaminergic neurons. Int J Neuropsychopharmacol, 14 (2): 211-23. [PMID:20149268] |