dasotraline

Ligand id: 8308

Name: dasotraline

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 26.02
Molecular weight 291.06
XLogP 5.48
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

References
1. Chen Z, Skolnick P. (2007)
Triple uptake inhibitors: therapeutic potential in depression and beyond.
Expert Opin Investig Drugs16 (9): 1365-77. [PMID:17714023]
2. DeLorenzo C, Lichenstein S, Schaefer K, Dunn J, Marshall R, Organisak L, Kharidia J, Robertson B, Mann JJ, Parsey RV. (2011)
SEP-225289 serotonin and dopamine transporter occupancy: a PET study.
J Nucl Med.52 (7): 1150-5. [PMID:21680689]
3. Guiard BP, Chenu F, El Mansari M, Blier P. (2011)
Characterization of the electrophysiological properties of triple reuptake inhibitors on monoaminergic neurons.
Int. J. Neuropsychopharmacol.14 (2): 211-23. [PMID:20149268]