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Synonyms: REGN-910 | REGN910 | SAR307746
Compound class:
Antibody
Comment: Nesvacumab is a fully human monoclonal antibody that targets angiopoietin-2 (ANGPT2, aka ANG2), being investigated as an antiangiogenic anti-tumour agent.
Peptide sequences for this antibody are available from its IMGT/mAb-DB record. |
| References |
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1. Daly C, Eichten A, Castanaro C, Pasnikowski E, Adler A, Lalani AS, Papadopoulos N, Kyle AH, Minchinton AI, Yancopoulos GD et al.. (2013)
Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition. Cancer Res, 73 (1): 108-18. [PMID:23149917] |
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2. Gerald D, Chintharlapalli S, Augustin HG, Benjamin LE. (2013)
Angiopoietin-2: an attractive target for improved antiangiogenic tumor therapy. Cancer Res, 73 (6): 1649-57. [PMID:23467610] |
