BI-2536

Ligand id: 5666

Name: BI-2536

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 8
Topological polar surface area 102.93
Molecular weight 521.31
XLogP 2.73
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Large-scale screening data

DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 2,4

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action Affinity Units
polo like kinase 1 PLK1 Hs Inhibitor Inhibition 9.7 pKd
polo like kinase 2 PLK2 Hs Inhibitor Inhibition 9.1 pKd
polo like kinase 3 PLK3 Hs Inhibitor Inhibition 8.4 pKd
ribosomal protein S6 kinase A4 RPS6KA4(Kin.Dom.2-C-terminal) Hs Inhibitor Inhibition 7.9 pKd
calcium/calmodulin dependent protein kinase kinase 1 CAMKK1 Hs Inhibitor Inhibition 7.7 pKd
calcium/calmodulin dependent protein kinase kinase 2 CAMKK2 Hs Inhibitor Inhibition 7.6 pKd
myosin light chain kinase MYLK Hs Inhibitor Inhibition 7.0 pKd
phosphatidylinositol-5-phosphate 4-kinase type 2 gamma PIP5K2C Hs Inhibitor Inhibition 7.0 pKd
death associated protein kinase 3 DAPK3 Hs Inhibitor Inhibition 6.9 pKd
protein tyrosine kinase 2 FAK Hs Inhibitor Inhibition 6.8 pKd
Displaying the top 10 targets  View all targets in screen »