phosphatidylinositol-5-phosphate 4-kinase type 2 gamma

Target id: 2163

Nomenclature: phosphatidylinositol-5-phosphate 4-kinase type 2 gamma

Abbreviated Name: PIP4K2C

Family: Phosphatidylinositol phosphate kinases, Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family)

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for phosphatidylinositol-5-phosphate 4-kinase type 2 gamma in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 421 12q13.2 PIP4K2C phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
Mouse - 421 10 D3 Pip4k2c phosphatidylinositol-5-phosphate 4-kinase, type II, gamma
Rat - 421 7 q22 Pip4k2c phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
Previous and Unofficial Names
phosphatidylinositol 5-phosphate 4-kinase type-2 gamma | PIP4KII-gamma | PIP5K2C | phosphatidylinositol-5-phosphate 4-kinase, type II, gamma | phosphatidylinositol-5-phosphate 4-kinase
Database Links
BRENDA
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Human Phosphatidylinositol-4-phosphate 5-kinase, type II, gamma
PDB Id:  2GK9
Resolution:  2.8Å
Species:  Human
References: 
Enzyme Reaction
EC Number: 2.7.1.149
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: PIP5K2C
Ligand Sp. Type Action Affinity Units
foretinib Hs Inhibitor Inhibition 7.6 pKd
BI-2536 Hs Inhibitor Inhibition 7.0 pKd
tamatinib Hs Inhibitor Inhibition 6.9 pKd
PD-173955 Hs Inhibitor Inhibition 6.6 pKd
pazopanib Hs Inhibitor Inhibition 6.6 pKd
imatinib Hs Inhibitor Inhibition 6.4 pKd
TG-100-115 Hs Inhibitor Inhibition 6.3 pKd
PI-103 Hs Inhibitor Inhibition 6.2 pKd
PP-242 Hs Inhibitor Inhibition 6.1 pKd
alvocidib Hs Inhibitor Inhibition 6.1 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

Phosphatidylinositol phosphate kinases: phosphatidylinositol-5-phosphate 4-kinase type 2 gamma. Last modified on 13/08/2015. Accessed on 20/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2163.