Akt inhibitor IV

Ligand id: 5919

Name: Akt inhibitor IV

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 6
Topological polar surface area 53.18
Molecular weight 487.2
XLogP 10.11
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Large-scale screening data

EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: 1,3

Key to terms and symbols Click column headers to sort
Target Name in screen Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
death associated protein kinase 1 DAPK1/DAPK1 Hs Inhibitor Inhibition 74.7 79.0 51.0
EPH receptor A1 EphA1/EPHA1 Hs Inhibitor Inhibition 77.1 100.0 100.0
protein kinase C alpha PKCα/PKCa Hs Inhibitor Inhibition 77.7 112.0 103.0
protein kinase N2 PRK2/PKN2(PRK2) Hs Inhibitor Inhibition 79.2 94.0 77.0
serine/threonine kinase 39 nd/STK39(STLK3) Hs Inhibitor Inhibition 81.1
fibroblast growth factor receptor 4 FGFR4/FGFR4 Hs Inhibitor Inhibition 84.1 101.0 84.0
protein kinase N1 nd/PKN1(PRK1) Hs Inhibitor Inhibition 85.7
WNK lysine deficient protein kinase 3 WNK3/WNK3 Hs Inhibitor Inhibition 85.9 100.0 44.0
conserved helix-loop-helix ubiquitous kinase IKKα/IKKA(CHUK) Hs Inhibitor Inhibition 86.0 92.0 93.0
beta adrenergic receptor kinase 1 nd/GRK2 Hs Inhibitor Inhibition 87.5
Displaying the top 10 targets  View all targets in screen »