trifluoperazine

Ligand id: 214

Name: trifluoperazine

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: trifluoperazine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 35.02
Molecular weight 407.16
XLogP 5.12
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes (FDA (1959))
IUPAC Name
10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine
International Nonproprietary Names
INN number INN
718 trifluoperazine
Synonyms
Eskazinyl® | Stelazine® | trifluoperazine hydrochloride
Database Links
BindingDB Ligand 50001886
CAS Registry No. 117-89-5 (source: Scifinder)
ChEBI CHEBI:45951
ChEMBL Ligand CHEMBL422
DrugBank Ligand DB00831
PubChem CID 5566
RCSB PDB Ligand TFP
Search Google for chemical match using the InChIKey ZEWQUBUPAILYHI-UHFFFAOYSA-N
Search Google for chemicals with the same backbone ZEWQUBUPAILYHI
Search PubMed clinical trials trifluoperazine
Search PubMed titles trifluoperazine
Search PubMed titles/abstracts trifluoperazine
Search UniChem for chemical match using the InChIKey ZEWQUBUPAILYHI-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone ZEWQUBUPAILYHI
Wikipedia Trifluoperazine
Comments
Trifluoperazine is a phenothiazine class typical antipsychotic drug, acting principally as a dopamine D2 receptor antagonist.