Ligand id: 214

Name: trifluoperazine

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: trifluoperazine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 5
Topological polar surface area 35.02
Molecular weight 407.16
XLogP 5.12
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Antipsychotic used in the treatment of schizophrenia and anxiety disorders. Has additional antiemetic action.
Mechanism Of Action and Pharmacodynamic Effects
Primarily acts as an antagonist of the dopamine D2 receptor in the brain, depressing the release of hypothalmic and hypophyseal hormones.
External links