trastuzumab emtansine

Ligand id: 6928

Name: trastuzumab emtansine

Classification
Compound class Antibody
Approved drug? Yes (FDA (2013))
International Nonproprietary Names
INN number INN
9295 trastuzumab emtansine
Synonyms
ado-trastuzumab emtansine | Kadcyla® | PRO-132365 | RG-3502
Database Links
Specialist databases
IMGT/mAb-DB 357
Other databases
PubChem SID 178103510
Search PubMed clinical trials trastuzumab emtansine
Search PubMed titles trastuzumab emtansine
Search PubMed titles/abstracts trastuzumab emtansine
Wikipedia Trastuzumab_emtansine
Comments
Trastuzumab emtansine is a antobody-drug conjugate (ADC) containing a targeting antibody (anti-erbB2) conjugated to a cytotoxic drug (mertansine or DM1) [2]. The PubChem ID for the mertasine component compound is CID 11343137. Mertansine (or DM1) is a macrolide of the ansamycin type and can be isolated from plants of the genus Maytenus. It is known as a maytansinoid. This agent binds to the rhizoxin binding site on β- tubulin and functions in a similar fashion to the Vinca alkaloids.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.