atezolizumab

Ligand id: 7990

Name: atezolizumab

Classification
Compound class Antibody
Approved drug? Yes (FDA (2016))
International Nonproprietary Names
INN number INN
9814 atezolizumab
Synonyms
MPDL3280A | Tecentriq®
Database Links
Specialist databases
IMGT/mAb-DB 526
Other databases
GtoPdb PubChem SID 249565671
Search PubMed clinical trials atezolizumab
Search PubMed titles atezolizumab
Search PubMed titles/abstracts atezolizumab
Wikipedia Atezolizumab
Comments
Atezolizumab (MPDL3280A) is a monoclonal antibody directed against programmed death-1 ligand-1 (PD-L1, aka CD274), an important immunopharmacological drug discovery target in immuno-oncology.
Peptide sequence and structural information for this antibody are available from its IMGT/mAb-db record. Peptide sequence analysis using the light chain variable region of atezolizumab provides a 100% match to sequence 21 from patent US8217149. An X-ray crystal structure of the PD-L1/atezolizumab complex has been submitted to the RCSB PDB (accession 5X8L) [2].