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Lipoxygenases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The lipoxygenases (LOXs) are a structurally related family of non-heme iron dioxygenases that function in the production, and in some cases metabolism, of fatty acid hydroperoxides. For arachidonic acid as substrate, these products are hydroperoxyeicosatetraenoic acids (HPETEs). In humans there are five lipoxygenases, the 5S-(arachidonate : oxygen 5-oxidoreductase), 12R-(arachidonate 12-lipoxygenase, 12R-type), 12S-(arachidonate : oxygen 12-oxidoreductase), and two distinct 15S-(arachidonate : oxygen 15-oxidoreductase) LOXs that oxygenate arachidonic acid in different positions along the carbon chain and form the corresponding 5S-, 12S-, 12R-, or 15S-hydroperoxides, respectively.

Enzymes

1390
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5-LOX C Show summary » More detailed page go icon to follow link

12R-LOX C Show summary »

12S-LOX C Show summary » More detailed page go icon to follow link

15-LOX-1 C Show summary » More detailed page go icon to follow link

15-LOX-2 C Show summary » More detailed page go icon to follow link

E-LOX C Show summary »


Target Id 1390
Nomenclature E-LOX
Previous and unofficial names Epidermis type LOX 3 | arachidonate lipoxygenase 3 | epidermis-type lipoxygenase 3 | eLOX3
Genes ALOXE3 (Hs), Aloxe3 (Mm), Aloxe3 (Rn)
Ensembl ID ENSG00000179148 (Hs), ENSMUSG00000020892 (Mm), ENSRNOG00000007454 (Rn)
UniProtKB AC Q9BYJ1 (Hs), Q9WV07 (Mm)
EC number
1.13.11.-
Endogenous substrates
12R-HPETE
Comment E-LOX metabolises the product from the 12R-lipoxygenase (12R-HPETE) to a specific epoxyalcohol compound [17].

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References

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NC-IUPHAR subcommittee and family contributors

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How to cite this family page

Database page citation (select format):

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Enzymes. Br J Pharmacol. 180 Suppl 2:S289-373.