citron rho-interacting serine/threonine kinase | Other DMPK family kinases | IUPHAR/BPS Guide to PHARMACOLOGY

citron rho-interacting serine/threonine kinase

Target id: 1509

Nomenclature: citron rho-interacting serine/threonine kinase

Abbreviated Name: CRIK

Family: Other DMPK family kinases

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for citron rho-interacting serine/threonine kinase in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 2027 12q24.23 CIT citron rho-interacting serine/threonine kinase
Mouse - 2055 5 F Cit citron
Rat - 2055 12q16 Cit citron rho-interacting serine/threonine kinase
Previous and Unofficial Names
citron-K kinase | postsynaptic density protein (citron) | Cit-k | citron-N | CRIK-SK | serine/threonine-protein kinase 21 | STK21 | citron (rho-interacting, serine/threonine kinase 21)
Database Links
BRENDA
CATH/Gene3D
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.1
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: CIT
Ligand Sp. Type Action Affinity Units
A-674563 Hs Inhibitor Inhibition 7.9 pKd
AST-487 Hs Inhibitor Inhibition 7.3 pKd
lestaurtinib Hs Inhibitor Inhibition 7.1 pKd
CHIR-265 Hs Inhibitor Inhibition 7.1 pKd
SU-14813 Hs Inhibitor Inhibition 7.0 pKd
alvocidib Hs Inhibitor Inhibition 7.0 pKd
fedratinib Hs Inhibitor Inhibition 6.8 pKd
GSK690693 Hs Inhibitor Inhibition 6.7 pKd
motesanib Hs Inhibitor Inhibition 6.5 pKd
staurosporine Hs Inhibitor Inhibition 6.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

Other DMPK family kinases: citron rho-interacting serine/threonine kinase. Last modified on 19/03/2013. Accessed on 14/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1509.