mitogen-activated protein kinase 6 | ERK subfamily | IUPHAR/BPS Guide to PHARMACOLOGY

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mitogen-activated protein kinase 6

Target id: 2092

Nomenclature: mitogen-activated protein kinase 6

Abbreviated Name: ERK3

Family: ERK subfamily

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for mitogen-activated protein kinase 6 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 721 15q21 MAPK6 mitogen-activated protein kinase 6
Mouse - 720 9 D Mapk6 mitogen-activated protein kinase 6
Rat - 720 8 q24 Mapk6 mitogen-activated protein kinase 6
Previous and Unofficial Names
MAP kinase 6 | p55-MAPK | p97-MAPK | Prkm4 | PRKM6 | extracellular signal-regulated kinase 3
Database Links
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
Description:  Crystal structure of human mitogen activated protein kinase 6 (MAPK6)
PDB Id:  2I6L
Resolution:  2.25Å
Species:  Human
References: 
Enzyme Reaction
EC Number: 2.7.11.24
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: ERK3
Ligand Sp. Type Action Affinity Units
PD-173955 Hs Inhibitor Inhibition 6.8 pKd
BMS-387032 Hs Inhibitor Inhibition 6.3 pKd
fedratinib Hs Inhibitor Inhibition 5.9 pKd
vandetanib Hs Inhibitor Inhibition 5.8 pKd
gefitinib Hs Inhibitor Inhibition 5.8 pKd
canertinib Hs Inhibitor Inhibition 5.8 pKd
SB203580 Hs Inhibitor Inhibition <5.5 pKd
ruboxistaurin Hs Inhibitor Inhibition <5.5 pKd
erlotinib Hs Inhibitor Inhibition <5.5 pKd
GSK690693 Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

ERK subfamily: mitogen-activated protein kinase 6. Last modified on 19/01/2015. Accessed on 13/12/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2092.