phosphatidylinositol-5-phosphate 4-kinase type 2 beta | Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family) | IUPHAR/BPS Guide to PHARMACOLOGY

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phosphatidylinositol-5-phosphate 4-kinase type 2 beta

Target id: 2162

Nomenclature: phosphatidylinositol-5-phosphate 4-kinase type 2 beta

Abbreviated Name: PIP4K2B

Family: Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family), Phosphatidylinositol phosphate kinases

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for phosphatidylinositol-5-phosphate 4-kinase type 2 beta in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 603 17q21.2 PIP4K2B phosphatidylinositol-5-phosphate 4-kinase type 2 beta
Mouse - 603 11 D Pip4k2b phosphatidylinositol-5-phosphate 4-kinase, type II, beta
Rat - 416 10 q31 Pip4k2b phosphatidylinositol-5-phosphate 4-kinase type 2 beta
Previous and Unofficial Names
PI5P4Kbeta | 1-phosphatidylinositol 5-phosphate 4-kinase 2-beta | 1-phosphatidylinositol-5-phosphate 4-kinase B | diphosphoinositide kinase 2-beta | PIP4KII-beta | PIP5K2B | PIP5KIIB | phosphatidylinositol-5-phosphate 4-kinase, type II, beta | phosphatidylinositol-5-phosphate 4-kinase
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Selected 3D Structures
Image of receptor 3D structure from RCSB PDB
PDB Id:  1BO1
Resolution:  3.0Å
Species:  Human
References:  2
Enzyme Reaction
EC Number:
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
Reference: 1,3

Key to terms and symbols Click column headers to sort
Target used in screen: PIP5K2B
Ligand Sp. Type Action Affinity Units
lestaurtinib Hs Inhibitor Inhibition 7.7 pKd
sunitinib Hs Inhibitor Inhibition 7.4 pKd
staurosporine Hs Inhibitor Inhibition 7.1 pKd
KW-2449 Hs Inhibitor Inhibition 7.0 pKd
tozasertib Hs Inhibitor Inhibition 6.8 pKd
fedratinib Hs Inhibitor Inhibition 6.8 pKd
dovitinib Hs Inhibitor Inhibition 6.6 pKd
SU-14813 Hs Inhibitor Inhibition 6.6 pKd
midostaurin Hs Inhibitor Inhibition 6.6 pKd
ruboxistaurin Hs Inhibitor Inhibition 6.1 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »


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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Rao VD, Misra S, Boronenkov IV, Anderson RA, Hurley JH. (1998) Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation. Cell, 94 (6): 829-39. [PMID:9753329]

3. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

Type II PIP kinases (1-phosphatidylinositol-5-phosphate 4-kinase family): phosphatidylinositol-5-phosphate 4-kinase type 2 beta. Last modified on 19/08/2015. Accessed on 20/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY,