pregnancy up-regulated nonubiquitous CaM kinase

Target id: 2172

Nomenclature: pregnancy up-regulated nonubiquitous CaM kinase

Abbreviated Name: CaMK1-beta

Family: CAMK1 family

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for pregnancy up-regulated nonubiquitous CaM kinase in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 426 Xq28 PNCK pregnancy up-regulated nonubiquitous CaM kinase
Mouse - 343 X A7.3 Pnck pregnancy upregulated non-ubiquitously expressed CaM kinase
Rat - 343 X q37 Pnck pregnancy up-regulated nonubiquitous CaM kinase
Previous and Unofficial Names
Bstk3 | caM kinase IB | caM-KI beta | Punc | pregnancy up-regulated non-ubiquitously expressed CaM kinase
Database Links
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.17
EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: ...1

Key to terms and symbols Click column headers to sort
Target used in screen: nd/CAMK1b
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
staurosporine Hs Inhibitor Inhibition 4.8
SB 218078 Hs Inhibitor Inhibition 50.5
K-252a Hs Inhibitor Inhibition 55.7
Syk inhibitor II Hs Inhibitor Inhibition 57.3
Syk inhibitor Hs Inhibitor Inhibition 58.1
SU11652 Hs Inhibitor Inhibition 70.5
PDK1/Akt/Flt dual pathway inhibitor Hs Inhibitor Inhibition 83.4
SU9516 Hs Inhibitor Inhibition 86.3
VEGF receptor 2 kinase inhibitor I Hs Inhibitor Inhibition 88.6
Cdk1/2 inhibitor III Hs Inhibitor Inhibition 89.1
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1039-45. [PMID:22037377]

How to cite this page

CAMK1 family: pregnancy up-regulated nonubiquitous CaM kinase. Last modified on 21/03/2013. Accessed on 24/05/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2172.