pregnancy up-regulated nonubiquitous CaM kinase

Target id: 2172

Nomenclature: pregnancy up-regulated nonubiquitous CaM kinase

Abbreviated Name: CaMK1-beta

Family: CAMK1 family

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for pregnancy up-regulated nonubiquitous CaM kinase in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 426 Xq28 PNCK pregnancy up-regulated nonubiquitous CaM kinase
Mouse - 343 X A7.3 Pnck pregnancy upregulated non-ubiquitously expressed CaM kinase
Rat - 343 X q37 Pnck pregnancy up-regulated nonubiquitous CaM kinase
Previous and Unofficial Names
Bstk3 | caM kinase IB | caM-KI beta | Punc | pregnancy up-regulated non-ubiquitously expressed CaM kinase
Database Links
BRENDA
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.17
EMD Millipore KinaseProfilerTM screen/Reaction Biology Kinase HotspotSM screen
A screen profiling 158 kinase inhibitors (Calbiochem Protein Kinase Inhibitor Library I and II, catalogue numbers 539744 and 539745) for their inhibitory activity at 1µM and 10µM against 234 human recombinant kinases using the EMD Millipore KinaseProfilerTM service.

A screen profiling the inhibitory activity of 178 commercially available kinase inhibitors at 0.5µM against a panel of 300 recombinant protein kinases using the Reaction Biology Corporation Kinase HotspotSM platform.

http://www.millipore.com/techpublications/tech1/pf3036
http://www.reactionbiology.com/webapps/main/pages/kinase.aspx


Reference: ...1

Key to terms and symbols Click column headers to sort
Target used in screen: nd/CAMK1b
Ligand Sp. Type Action % Activity remaining at 0.5µM % Activity remaining at 1µM % Activity remaining at 10µM
staurosporine Hs Inhibitor Inhibition 4.8
SB 218078 Hs Inhibitor Inhibition 50.5
K-252a Hs Inhibitor Inhibition 55.7
Syk inhibitor II Hs Inhibitor Inhibition 57.3
Syk inhibitor Hs Inhibitor Inhibition 58.1
SU11652 Hs Inhibitor Inhibition 70.5
PDK1/Akt/Flt dual pathway inhibitor Hs Inhibitor Inhibition 83.4
SU9516 Hs Inhibitor Inhibition 86.3
VEGF receptor 2 kinase inhibitor I Hs Inhibitor Inhibition 88.6
Cdk1/2 inhibitor III Hs Inhibitor Inhibition 89.1
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR. (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat. Biotechnol.29 (11): 1039-45. [PMID:22037377]

How to cite this page

CAMK1 family: pregnancy up-regulated nonubiquitous CaM kinase. Last modified on 21/03/2013. Accessed on 20/11/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2172.