serine/threonine kinase 35 | NKF4 family | IUPHAR/BPS Guide to PHARMACOLOGY

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serine/threonine kinase 35

Target not currently curated in GtoImmuPdb

Target id: 2222

Nomenclature: serine/threonine kinase 35

Abbreviated Name: CLIK1

Family: NKF4 family

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 534 20p13 STK35 serine/threonine kinase 35
Mouse - 539 2 F1 Stk35 serine/threonine kinase 35
Rat - 604 3 q36 Stk35 serine/threonine kinase 35
Previous and Unofficial Names
CLIK1 | CLP-36 interacting kinase | Stk35l1
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: STK35
Ligand Sp. Type Action Affinity Parameter
bosutinib Hs Inhibitor Inhibition 8.7 pKd
cediranib Hs Inhibitor Inhibition 8.3 pKd
SU-14813 Hs Inhibitor Inhibition 8.1 pKd
AST-487 Hs Inhibitor Inhibition 7.8 pKd
brivanib Hs Inhibitor Inhibition 7.6 pKd
vandetanib Hs Inhibitor Inhibition 7.3 pKd
staurosporine Hs Inhibitor Inhibition 6.8 pKd
foretinib Hs Inhibitor Inhibition 6.6 pKd
NVP-TAE684 Hs Inhibitor Inhibition 6.6 pKd
PD-173955 Hs Inhibitor Inhibition 6.4 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »


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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

NKF4 family: serine/threonine kinase 35. Last modified on 18/08/2014. Accessed on 24/04/2019. IUPHAR/BPS Guide to PHARMACOLOGY,