dipeptidyl peptidase 9

Target id: 2357

Nomenclature: dipeptidyl peptidase 9

Family: S9: Prolyl oligopeptidase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for dipeptidyl peptidase 9 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 892 19p13.3 DPP9 dipeptidyl peptidase 9
Mouse - 862 17 D Dpp9 dipeptidylpeptidase 9
Rat - - 9q11 Dpp9 dipeptidyl peptidase 9
Previous and Unofficial Names
dipeptidyl peptidase IX | DP9 | DPP IX | DPRP2 | dipeptidyl-peptidase 9
Database Links
Specialist databases
MEROPS S09.019 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.14.5

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
compound 24dd [PMID: 20684603] Hs Inhibition 6.7 pKi 2
pKi 6.7 (Ki 1.9x10-7 M) [2]
1G244 Hs Inhibition 7.3 pIC50 3
pIC50 7.3 (IC50 5.3x10-8 M) [3]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Idiopathic pulmonary fibrosis
Disease Ontology: DOID:0050156
Orphanet: ORPHA2032
References:  1

References

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1. Fingerlin TE, Murphy E, Zhang W, Peljto AL, Brown KK, Steele MP, Loyd JE, Cosgrove GP, Lynch D, Groshong S et al.. (2013) Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. Nat. Genet.45 (6): 613-20. [PMID:23583980]

2. Meng W, Brigance RP, Chao HJ, Fura A, Harrity T, Marcinkeviciene J, O'Connor SP, Tamura JK, Xie D, Zhang Y et al.. (2010) Discovery of 6-(aminomethyl)-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2-carboxamides as potent, selective dipeptidyl peptidase-4 (DPP4) inhibitors. J. Med. Chem.53 (15): 5620-8. [PMID:20684603]

3. Wu JJ, Tang HK, Yeh TK, Chen CM, Shy HS, Chu YR, Chien CH, Tsai TY, Huang YC, Huang YL et al.. (2009) Biochemistry, pharmacokinetics, and toxicology of a potent and selective DPP8/9 inhibitor. Biochem. Pharmacol.78 (2): 203-10. [PMID:19439267]

How to cite this page

S9: Prolyl oligopeptidase: dipeptidyl peptidase 9. Last modified on 30/03/2016. Accessed on 22/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2357.