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ribonucleotide reductase regulatory subunit M2

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Target not currently curated in GtoImmuPdb

Target id: 2631

Nomenclature: ribonucleotide reductase regulatory subunit M2

Abbreviated Name: ribonucleotide reductase M2

Family: Nucleoside synthesis and metabolism, 1.17.4.1 Ribonucleoside-diphosphate reductases

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 389 2p25.1 RRM2 ribonucleotide reductase regulatory subunit M2
Mouse - 390 12 8.5 cM Rrm2 ribonucleotide reductase M2
Rat - 390 6q16 Rrm2 ribonucleotide reductase regulatory subunit M2
Previous and Unofficial Names Click here for help
ribonucleoside-diphosphate reductase subunit | Rrm2 | ribonucleotide reductase M2
Database Links Click here for help
Alphafold P31350 (Hs), P11157 (Mm), Q4KLN6 (Rn)
BRENDA 1.17.4.1
ChEMBL Target CHEMBL1954 (Hs), CHEMBL3527 (Mm)
DrugBank Target P31350 (Hs)
Ensembl Gene ENSG00000171848 (Hs), ENSMUSG00000020649 (Mm), ENSRNOG00000054286 (Rn)
Entrez Gene 6241 (Hs), 20135 (Mm), 362720 (Rn)
Human Protein Atlas ENSG00000171848 (Hs)
KEGG Enzyme 1.17.4.1
KEGG Gene hsa:6241 (Hs), mmu:20135 (Mm), rno:362720 (Rn)
OMIM 180390 (Hs)
Pharos P31350 (Hs)
RefSeq Nucleotide NM_001165931 (Hs), NM_009104 (Mm), NM_001025740 (Rn)
RefSeq Protein NP_001159403 (Hs), NP_033130 (Mm), NP_001020911 (Rn)
UniProtKB P31350 (Hs), P11157 (Mm), Q4KLN6 (Rn)
Wikipedia RRM2 (Hs)
Enzyme Reaction Click here for help
EC Number: 1.17.4.1

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
clofarabine Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 8.3 pIC50 2
⤷ pIC50 8.3 (IC50 5x10-9 M) [2]
Description: Inhibition of growth of K562 cells
fludarabine Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Hs Inhibition 6.0 pIC50 4
⤷ pIC50 6.0 (IC50 1x10-6 M) [4]
Description: Inhibition of ADP reduction by ribonucleotide reductase from HeLa cells
hydroxyurea Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 3.8 pIC50 3
⤷ pIC50 3.8 (IC50 1.48x10-4 M) [3]
Description: Dissolved in 1% DMSO, in vitro assay using reconstituted RRM1/RRM2 holoenzyme
gemcitabine Small molecule or natural product Approved drug Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition - - 1
⤷ [1]
Inhibitor Comments
Please see the Inhibitors table on the More detailed page for RRM1, for information on approved drugs which may act via this protein.

References

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1. Heinemann V, Xu YZ, Chubb S, Sen A, Hertel LW, Grindey GB, Plunkett W. (1990) Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2',2'-difluorodeoxycytidine. Mol Pharmacol, 38 (4): 567-72. [PMID:2233693]

2. Parker WB, Shaddix SC, Chang CH, White EL, Rose LM, Brockman RW, Shortnacy AT, Montgomery JA, Secrist 3rd JA, Bennett Jr LL. (1991) Effects of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate. Cancer Res, 51 (9): 2386-94. [PMID:1707752]

3. Shao J, Zhou B, Zhu L, Bilio AJ, Su L, Yuan YC, Ren S, Lien EJ, Shih J, Yen Y. (2005) Determination of the potency and subunit-selectivity of ribonucleotide reductase inhibitors with a recombinant-holoenzyme-based in vitro assay. Biochem Pharmacol, 69 (4): 627-34. [PMID:15670581]

4. Tseng WC, Derse D, Cheng YC, Brockman RW, Bennett Jr LL. (1982) In vitro biological activity of 9-beta-D-arabinofuranosyl-2-fluoroadenine and the biochemical actions of its triphosphate on DNA polymerases and ribonucleotide reductase from HeLa cells. Mol Pharmacol, 21 (2): 474-7. [PMID:7048062]

How to cite this page

Nucleoside synthesis and metabolism: ribonucleotide reductase regulatory subunit M2. Last modified on 28/11/2018. Accessed on 19/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2631.