eukaryotic translation elongation factor 2

Target id: 2756

Nomenclature: eukaryotic translation elongation factor 2

Family: Ribosomal factors

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for eukaryotic translation elongation factor 2 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 858 19p13.3 EEF2 eukaryotic translation elongation factor 2
Mouse - 858 10 C1 Eef2 eukaryotic translation elongation factor 2
Rat - 858 7q11 Eef2 eukaryotic translation elongation factor 2
Previous and Unofficial Names
EEF-2 | polypeptidyl-tRNA translocase
Database Links
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Inhibitor Comments
Denileukin diftitox is an immunotoxic inhibitor of EEF2 (elongation factor 2). EEF2 is the primary target of the diptheria toxin [2,4] liberated upon intracellular processing of the endocytically internalised drug [3]. Denileukin diftitox inhibits protein synthesis in IL-2 receptor +ve cells (human C91/PL T cells) with an IC50 of 0.01nM [1] but protein synthesis is not inhibited in IL-2 receptor -ve cells in the same study.
Clinically-Relevant Mutations and Pathophysiology
Disease:  Spinocerebellar ataxia 26; SCA26
OMIM: 609306
Orphanet: ORPHA101112

References

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1. Bacha P, Williams DP, Waters C, Williams JM, Murphy JR, Strom TB. (1988) Interleukin 2 receptor-targeted cytotoxicity. Interleukin 2 receptor-mediated action of a diphtheria toxin-related interleukin 2 fusion protein. J. Exp. Med.167 (2): 612-22. [PMID:3126255]

2. Deng Q, Barbieri JT. (2008) Molecular mechanisms of the cytotoxicity of ADP-ribosylating toxins. Annu. Rev. Microbiol.62: 271-88. [PMID:18785839]

3. Jørgensen R, Merrill AR, Yates SP, Marquez VE, Schwan AL, Boesen T, Andersen GR. (2005) Exotoxin A-eEF2 complex structure indicates ADP ribosylation by ribosome mimicry. Nature436 (7053): 979-84. [PMID:16107839]

4. Jørgensen R, Purdy AE, Fieldhouse RJ, Kimber MS, Bartlett DH, Merrill AR. (2008) Cholix toxin, a novel ADP-ribosylating factor from Vibrio cholerae. J. Biol. Chem.283 (16): 10671-8. [PMID:18276581]

How to cite this page

Ribosomal factors: eukaryotic translation elongation factor 2. Last modified on 13/08/2015. Accessed on 15/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2756.