Glucokinase | Hexokinases | IUPHAR/BPS Guide to PHARMACOLOGY

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Glucokinase

Target not currently curated in GtoImmuPdb

Target id: 2798

Nomenclature: Glucokinase

Family: Hexokinases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 465 7p15.3-p15.1 GCK glucokinase
Mouse - 465 11 A1 Gck glucokinase
Rat - 498 14q21 Gck glucokinase
Gene and Protein Information Comments
In humans, the 465 amino acid form (isoform 1, NM_000162) is expressed specifically in pancreatic β cells. Isoforms 2 (466 amino acids, NM_NM_033507) and 3 (464 amino acids, NM_033508) are expressed in the liver, with isoform 2 being the predominant hepatic variant. The mouse expresses two isoforms; isoform 1 (465 amino acids, NM_010292) in pancreatic β cells and isoform 2 (465 amino acids, NM_001287386) in the liver.
Previous and Unofficial Names
glucokinase (hexokinase 4)
Database Links
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
AZD1656 Hs Activation 7.2 pEC50 1
pEC50 7.2 (EC50 5.7x10-8 M) [1]
Clinically-Relevant Mutations and Pathophysiology
Disease:  Diabetes mellitus, noninsulin-dependent; NIDDM
Synonyms: Diabetes mellitus, Type II; T2D [OMIM: 125853]
Maturity onset diabetes
Type 2 diabetes mellitus [Disease Ontology: DOID:9352]
Disease Ontology: DOID:9352
OMIM: 125853
Disease:  Diabetes mellitus, permanent neonatal; PNDM
Synonyms: DEND syndrome [Orphanet: ORPHA79134]
Developmental delay-epilepsy-neonatal diabetes syndrome [Orphanet: ORPHA79134]
Permanent neonatal diabetes mellitus [Orphanet: ORPHA99885]
OMIM: 606176
Orphanet: ORPHA99885, ORPHA79134
Disease:  Hyperinsulinemic hypoglycemia, familial, 3; HHF3
Synonyms: Hyperinsulinemic hypoglycemia [Disease Ontology: DOID:13317]
Hyperinsulinism due to glucokinase deficiency [Orphanet: ORPHA79299]
Disease Ontology: DOID:13317
OMIM: 602485
Orphanet: ORPHA79299
Disease:  Maturity-onset diabetes of the young, type 2; MODY2
Synonyms: Maturity-onset diabetes of the young [Orphanet: ORPHA552] [OMIM: 606391] [Disease Ontology: DOID:0050524]
MODY [Orphanet: ORPHA552] [OMIM: 606391]
Disease Ontology: DOID:0050524
OMIM: 125851, 606391
Orphanet: ORPHA552
Role: 

References

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1. AstraZeneca. AZD1656. Accessed on 17/09/2014. Modified on 17/09/2014. astrazeneca.com, http://openinnovation.astrazeneca.com/what-we-offer/compound/azd1656/

How to cite this page

Hexokinases: Glucokinase. Last modified on 15/04/2015. Accessed on 19/07/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2798.