Ca<sub>v</sub>1.3 | Voltage-gated calcium channels | IUPHAR/BPS Guide to PHARMACOLOGY

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Cav1.3

Target id: 530

Nomenclature: Cav1.3

Family: Voltage-gated calcium channels

Annotation status:  image of a green circle Annotated and expert reviewed. Please contact us if you can help with updates.  » Email us

   GtoImmuPdb view: OFF :     Cav1.3 has curated data in GtoImmuPdb

Gene and Protein Information
Species TM P Loops AA Chromosomal Location Gene Symbol Gene Name Reference
Human 24 4 2181 3p14.3 CACNA1D calcium voltage-gated channel subunit alpha1 D 29,52
Mouse 24 4 2166 14 B Cacna1d calcium channel, voltage-dependent, L type, alpha 1D subunit 67
Rat 24 4 2203 16p16 Cacna1d calcium voltage-gated channel subunit alpha1 D 24,68
Previous and Unofficial Names
neuroendocrine L-type Ca2+ channel | α1D | CACH3 | CACN4 | CACNL1A2 | CCHL1A2 | calcium channel alpha-1 subunit | Cchl1a | calcium channel
Database Links
ChEMBL Target
DrugBank Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
Orphanet
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Associated Proteins
Heteromeric Pore-forming Subunits
Name References
Not determined
Auxiliary Subunits
Name References
β
α 20,28-29,43,53,68
Other Associated Proteins
Name References
erbin 10
Shank 70
Densin 25
Rab3 interacting molecule (RIM) 15
RIM binding proteins 21
pp60 (c-src) 60
bestrophin 69
calcium binding proteins 1, 2 12,51
calmodulin 14,66
RGK protein family members 8
whirlin 26
harmonin 18-19
otoferlin 46
retinoschisin 54
A-kinase anchoring proteins (15, MAP2B) 34
ankyrin 13
RyR2 27
Functional Characteristics
L-type calcium current: Voltage-activated, slow voltage-dependent inactivation, more rapid calcium-dependent inactivation
Ion Selectivity and Conductance
Species:  Human
Single channel conductance (pS):  14.9-16.1 (15 mM Ba2+)
References:  4
Voltage Dependence
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  -20.0 - 68 Xenopus laevis oocyte Rat
Inactivation  - -
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  -39.0 – -1.3 (median: -28.4) 1.2 – 4.5 20,45,53,58,68 HEK-293, tsA-201 Rat
Inactivation  -58.8 – -33.5 (median: -35.4) 6.8 – 71.0 45,53
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  -19.6 – 15.0 0.3 5,37,41 Cochlear outer and inner hair cells Mouse
Inactivation  -25.0 10.0 – 200.0 17,37
Comments  Activation thresholds at physiological extracellular calcium concentrations are between -50 and -65mV. ICa is mostly (>90%) Cav1.3 current [37,41].

Inactivation parameters are for outer hair cells only, as inactivation is much slower in inner hair cells [37].
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  -19.3 – 26.5 0.3 17,58 Cochlear inner hair cells Rat
Inactivation  - -
Comments  Calcium-dependent inactivation is present in IHCs but the overall inactivation process is slower than in Cav1.3 currents in other tissues (e.g. sinoatrial node cells [32]).
  V0.5 (mV)  τ (msec)  Reference  Cell type  Species 
Activation  -20.2 – -2.2 (median: -12.9) 0.5 – 2.5 29-30,55 HEK-293, tsA-201 Human
Inactivation  -42.7 3.8 – 74.0 29,55
Comments  Data are for 15 mM Ba2+ or Ca2+. Activation and inactivation parameters differ between two different C-terminal splice variants (long and short forms; [55]).
Voltage Dependence Comments
Data are given for both Ca2+ and Ba2+ as the charge carrier. V0.5 for activation is higher with Ca2+ as a charge carrier than with Ba2+ (but more negative than for Cav1.2 under identical experimental conditions; [68]).

Activation and inactivation parameters differ between different C-terminal splice variants (long and several short forms; [4,31,55,62]). Short forms lack a C-terminal modulatory domain which reduces calcium-dependent inactivation and reduces voltage-sensitivity.

Inactivation time course depends on associated β subunit (slower with β2), C-terminal splice variant and on charge carrier (pronounced calcium-induced inactivation with Ca2+; [55]).

Download all structure-activity data for this target as a CSV file

Activators
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
BAYK 8644 Hs - - - 5x10-6 -90.0 – -83.0 29,41
Conc range: 5x10-6 M [29,41]
Holding voltage: -90.0 – -83.0 mV
BAYK 8644 Rn - - - 1x10-6 -80.0 68
Conc range: 1x10-6 M [68]
Holding voltage: -80.0 mV
FPL64176 Hs - ~7.8 pEC50 - -
pEC50 ~7.8 (EC50 ~1.6x10-8 M)
(-)-(S)-BayK8644 Hs - ~7.8 pEC50 - -
pEC50 ~7.8 (EC50 ~1.73x10-8 M)
View species-specific activator tables
Activator Comments
Using rat channels, BAYK 8644 (1μM) shifted the V0.5 towards a more hyperpolarised voltage (-32.2mV to -39.0mV) [68].
Gating inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
isradipine Hs - - - 3x10-8 - 3x10-7 -90.0 – -50.0 29
Conc range: 3x10-8 - 3x10-7 M [29]
Holding voltage: -90.0 – -50.0 mV
[3H](+)-isradipine Hs - 9.4 pKd - - 29
pKd 9.4 [29]
isradipine Hs - 9.3 pIC50 - - 57
pIC50 9.3 (IC50 5.1x10-10 M) [57]
Description: Recombinant Cav1.3 calcium channel complexes expressed in tsA201-cells
azidopine Hs Inhibition 9.2 pIC50 - - 57
pIC50 9.2 (IC50 6.5x10-10 M) [57]
Description: Recombinant Cav1.3 calcium channel complexes expressed in tsA201-cells
nitrendipine Hs Inhibition 8.4 pIC50 - - 57
pIC50 8.4 (IC50 3.59x10-9 M) [57]
Description: Recombinant Cav1.3 calcium channel complexes expressed in tsA-cells
nifedipine Hs Antagonist 7.7 pIC50 - - 57
pIC50 7.7 (IC50 2.01x10-8 M) [57]
Description: Recombinant Cav1.3 calcium channel complexes expressed in tsA-cells
amlodipine Hs Inhibition 7.2 pIC50 - - 57
pIC50 7.2 (IC50 6.01x10-8 M) [57]
Description: Recombinant Cav1.3 calcium channel complexes expressed in tsA-cells
nisoldipine Mm - 6.4 – 7.0 pIC50 - -80.0 67
pIC50 6.4 – 7.0 [67]
Holding voltage: -80.0 mV
nimodipine Rn Antagonist 5.7 – 6.6 pIC50 - -80.0 – -40.0 47,68
pIC50 5.7 – 6.6 [47,68]
Holding voltage: -80.0 – -40.0 mV
View species-specific gating inhibitor tables
Gating Inhibitor Comments
Nitrendipine appears to interact more effectively with L-type calcium channels in smooth muscle cells. We have chosen to tag the drug's interaction with Cav1.3 as the primary drug target, but this does not preclude activity at other additional channels.
Channel Blockers
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Concentration range (M) Holding voltage (mV) Reference
Cd2+ N/A Antagonist - - 2x10-4 -60.0 50
Conc range: 2x10-4 M [50]
Holding voltage: -60.0 mV
verapamil Hs Antagonist - - - -
View species-specific channel blocker tables
Channel Blocker Comments
Verapamil is an example of a dihydropyridine antagonist; Cav1.3 is less sensitive to dihydropyridine antagonists than other members of this family.
Immunopharmacology Comments
Cav1.3 and Cav1.4 are involved in CD8+ T cell survival and cytokine production [40].
Cell Type Associations
Immuno Cell Type:  T cells
References:  63
Tissue Distribution
Atriventricular node, right atrial myocytes.
Species:  Human
Technique:  RT-PCR
References:  32
Brain (ubiquitious), spinal cord, dorsal root ganglion.
Species:  Human
Technique:  RT-PCR
References:  61
Lymphocytes.
Species:  Human
Technique:  RT-PCR, Western blotting
References:  59
Adrenal cortex (zona glomerulosa)
Species:  Human
Technique:  Microarray analysis
References:  1,49
Brain.
Species:  Mouse
Technique:  Radioligand binding.
References:  11
Adrenal chromaffin cells.
Species:  Mouse
Technique:  RT-PCR
References:  33
Retinal neurons.
Species:  Mouse
Technique:  Immunohistochemistry
References:  7
Lymphocytes.
Species:  Mouse
Technique:  RT-PCR, Western blotting
References:  2
Pancreatic islets.
Species:  Mouse
Technique:  RT-PCR
References:  65
Sinoatrial node pacemaker cells, right atrial myocytes
Species:  Mouse
Technique:  RT-PCR
References:  32
Hair cells (cochlea: inner and outer).
Species:  Mouse
Technique:  RT-PCR, electrophysiology (absence of currents in knockout mice)
References:  6,37
Atrial myocytes
Species:  Rat
Technique:  Immunocytochemistry
References:  45
Tissue Distribution Comments
The physiological role of Cav1.3 L-type channels for lymphocyte function is not well established. Additionally, in lymphocytes the presence of Cav1.3 α1 subunit protein has not yet been proven using Cav1.3-α1 deficient mice as negative controls; therefore the specificity of antibody staining remians questionable [9,59].
Functional Assays
Patch-clamp (whole cell currents) recording from cells derived from Cav1.3 knockout mice.
Species:  Mouse
Tissue:  Cochlear hair cells
Response measured:  L-type currents.
References:  5-6,37,41
Patch-clamp (whole cell currents) recording from cells derived from Cav1.3 knockout mice.
Species:  Mouse
Tissue:  Sinoatrial node cells
Response measured:  L-type currents.
References:  32,71
Patch-clamp (whole cell currents) recording from HEK-293 cells transfected with Cav1.3.
Species:  Human
Tissue:  HEK-293 cells
Response measured:  L-type currents.
References:  29-30,58
Patch-clamp (whole cell currents) recording from HEK-293 cells transfected with Cav1.3.
Species:  Rat
Tissue:  HEK-293 cells
Response measured:  L-type currents
References:  20,45,47,53,68
Two-electrode voltage clamp recording from Xenopus oocytes transfected with Cav1.3.
Species:  Rat
Tissue:  Xenpous oocytes
Response measured:  L-type currents
References:  68
Whole cell patch-clamp
Species:  Mouse
Tissue:  Adrenal chromaffin cells
Response measured:  Calcium inward current
References:  33,64
Physiological Functions
Sinoatrial node pacemaking.
Species:  Mouse
Tissue:  Heart.
References:  32,41,71
Hearing.
Species:  Mouse
Tissue:  Cochlea, inner ear.
References:  6,37,41
Brain (spontaneous neuronal activity).
Species:  Mouse
Tissue:  Medium spiny neurons.
References:  39
Brain function (consolidation of contextually conditioned fear; mood behaviour).
Species:  Mouse
Tissue:  Brain.
References:  35,56
Synaptic refinement in auditory brainstem
Species:  Mouse
Tissue:  Brain
References:  22
Fear memory consolidation, amygdala LTP
Species:  Mouse
Tissue:  Brain
References:  36
Long-term adaptation in dopamine D2L-mediated GluA1 trafficking in the dorsal striatum following cocaine exposure
Species:  Mouse
Tissue:  Brain
References:  48
Acquisition of psychostimulant-induced locomotor sensitization
Species:  Mouse
Tissue:  Brain
References:  16
Catacholamine secretion from adrenal chromaffin cells
Species:  Mouse
Tissue:  Adrenal chromaffin cells
References:  42
Physiological Consequences of Altering Gene Expression
Congenital deafness
Species:  Mouse
Tissue:  Cochlea, inner ear
Technique:  Knockout
References:  6,37,41
Sinus bradycardia and spontaneous arrhythmia
Species:  Mouse
Tissue:  Heart
Technique:  Knockout
References:  32,41,71
Phenotypes, Alleles and Disease Models Mouse data from MGI

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Allele Composition & genetic background Accession Phenotype Id Phenotype Reference
Cacna1dtm1Hssh Cacna1dtm1Hssh/Cacna1dtm1Hssh
involves: 129S4/SvJae * C57BL/6J
MGI:88293  MP:0004231 abnormal calcium ion homeostasis PMID: 11581302 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
involves: 129S7/SvEvBrd * C57BL/6J
MGI:88293  MP:0004231 abnormal calcium ion homeostasis PMID: 10929716 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
B6.129S7-Cacna1d
MGI:88293  MP:0004746 abnormal cochlear IHC afferent innervation pattern PMID: 12684182  14645476  16828974 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
B6.129S7-Cacna1d
MGI:88293  MP:0004633 abnormal cochlear IHC efferent innervation pattern PMID: 12684182  14645476  16828974 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
involves: 129S7/SvEvBrd * C57BL/6J
MGI:88293  MP:0004433 abnormal cochlear inner hair cell physiology PMID: 10929716  17074442 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
B6.129S7-Cacna1d
MGI:88293  MP:0004433 abnormal cochlear inner hair cell physiology PMID: 14645476  16828974 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
B6.129S7-Cacna1d
MGI:88293  MP:0004716 abnormal cochlear nerve morphology PMID: 12890513 
Cacna1dtm1Hssh Cacna1dtm1Hssh/Cacna1dtm1Hssh
involves: 129S4/SvJae * C57BL/6J
MGI:88293  MP:0004434 abnormal cochlear outer hair cell physiology PMID: 15357422 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
involves: 129S7/SvEvBrd * C57BL/6J
MGI:88293  MP:0004434 abnormal cochlear outer hair cell physiology PMID: 17074442 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
involves: 129S7/SvEvBrd * C57BL/6J
MGI:88293  MP:0004736 abnormal distortion product otoacoustic emission PMID: 17074442 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
B6.129S7-Cacna1d
MGI:88293  MP:0004562 abnormal inner hair cell synaptic ribbon morphology PMID: 16828974 
Cacna1dtm1Hssh Cacna1dtm1Hssh/Cacna1dtm1Hssh
involves: 129S4/SvJae * C57BL/6J
MGI:88293  MP:0009175 abnormal pancreatic beta cell differentiation PMID: 11581302 
Cacna1dtm1Hssh Cacna1dtm1Hssh/Cacna1dtm1Hssh
involves: 129S4/SvJae * C57BL/6J
MGI:88293  MP:0003562 abnormal pancreatic beta cell physiology PMID: 11581302 
Cacna1dtm1Hssh Cacna1dtm1Hssh/Cacna1dtm1Hssh
involves: 129S4/SvJae * C57BL/6J
MGI:88293  MP:0005215 abnormal pancreatic islet morphology PMID: 11581302 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
involves: 129S7/SvEvBrd * C57BL/6J
MGI:88293  MP:0006142 abnormal sinoatrial node conduction PMID: 10929716 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
involves: 129S7/SvEvBrd * C57BL/6J
MGI:88293  MP:0004122 abnormal sinus arrhythmia PMID: 10929716 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
B6.129S7-Cacna1d
MGI:88293  MP:0004563 absent active-zone-anchored inner hair cell synaptic ribbon PMID: 12684182 
Cacna1dtm1Hssh Cacna1dtm1Hssh/Cacna1dtm1Hssh
involves: 129S4/SvJae * C57BL/6J
MGI:88293  MP:0004763 absent brainstem auditory evoked potential PMID: 15357422 
Cacna1dtm1Hssh Cacna1dtm1Hssh/Cacna1dtm1Hssh
involves: 129S4/SvJae * C57BL/6J
MGI:88293  MP:0004737 absent distortion product otoacoustic emissions PMID: 15357422 
Cacna1dtm1Hssh Cacna1dtm1Hssh/Cacna1dtm1Hssh
involves: 129S4/SvJae * C57BL/6J
MGI:88293  MP:0004530 absent outer hair cell stereocilia PMID: 15357422 
Cacna1dtm1Hssh Cacna1dtm1Hssh/Cacna1dtm1Hssh
involves: 129S4/SvJae * C57BL/6J
MGI:88293  MP:0006358 absent pinna reflex PMID: 11581302  15357422 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
involves: 129S7/SvEvBrd * C57BL/6J
MGI:88293  MP:0006358 absent pinna reflex PMID: 10929716 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
B6.129S7-Cacna1d
MGI:88293  MP:0006358 absent pinna reflex PMID: 12684182  12890513 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
involves: 129S7/SvEvBrd * C57BL/6J
MGI:88293  MP:0010519 atrioventricular block PMID: 10929716 
Cacna1dtm1Hssh Cacna1dtm1Hssh/Cacna1dtm1Hssh
involves: 129S4/SvJae * C57BL/6J
MGI:88293  MP:0002857 cochlear ganglion degeneration PMID: 15357422 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
involves: 129S7/SvEvBrd * C57BL/6J
MGI:88293  MP:0002857 cochlear ganglion degeneration PMID: 10929716 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
B6.129S7-Cacna1d
MGI:88293  MP:0002857 cochlear ganglion degeneration PMID: 12684182  16828974 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
B6.129S7-Cacna1d
MGI:88293  MP:0004362 cochlear hair cell degeneration PMID: 12684182 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
involves: 129S7/SvEvBrd * C57BL/6J
MGI:88293  MP:0004398 cochlear inner hair cell degeneration PMID: 10929716 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
B6.129S7-Cacna1d
MGI:88293  MP:0004398 cochlear inner hair cell degeneration PMID: 12684182  12890513  16828974 
Cacna1dtm1Hssh Cacna1dtm1Hssh/Cacna1dtm1Hssh
involves: 129S4/SvJae * C57BL/6J
MGI:88293  MP:0004404 cochlear outer hair cell degeneration PMID: 15357422 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
involves: 129S7/SvEvBrd * C57BL/6J
MGI:88293  MP:0004404 cochlear outer hair cell degeneration PMID: 10929716  17074442 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
B6.129S7-Cacna1d
MGI:88293  MP:0004404 cochlear outer hair cell degeneration PMID: 12684182 
Cacna1dtm1Hssh Cacna1dtm1Hssh/Cacna1dtm1Hssh
involves: 129S4/SvJae * C57BL/6J
MGI:88293  MP:0001967 deafness PMID: 11581302  15357422 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
involves: 129S7/SvEvBrd * C57BL/6J
MGI:88293  MP:0001967 deafness PMID: 10929716  17074442 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
B6.129S7-Cacna1d
MGI:88293  MP:0001967 deafness PMID: 12684182 
Cacna1dtm1Hssh Cacna1dtm1Hssh/Cacna1dtm1Hssh
involves: 129S4/SvJae * C57BL/6J
MGI:88293  MP:0001262 decreased body weight PMID: 11581302 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
B6.129S7-Cacna1d
MGI:88293  MP:0001262 decreased body weight PMID: 12890513 
Cacna1dtm1Hssh Cacna1dtm1Hssh/Cacna1dtm1Hssh
involves: 129S4/SvJae * C57BL/6J
MGI:88293  MP:0004765 decreased brainstem auditory evoked potential PMID: 11581302 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
involves: 129S7/SvEvBrd * C57BL/6J
MGI:88293  MP:0004765 decreased brainstem auditory evoked potential PMID: 10929716  17074442 
Cacna1d+|Cacna1dtm1Hssh Cacna1dtm1Hssh/Cacna1d+
involves: 129S4/SvJae * C57BL/6J
MGI:88293  MP:0004765 decreased brainstem auditory evoked potential PMID: 15357422 
Cacna1dtm1Hssh Cacna1dtm1Hssh/Cacna1dtm1Hssh
involves: 129S4/SvJae * C57BL/6J
MGI:88293  MP:0002727 decreased circulating insulin level PMID: 11581302 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
involves: 129S7/SvEvBrd * C57BL/6J
MGI:88293  MP:0005333 decreased heart rate PMID: 10929716 
Cacna1dtm1Hssh Cacna1dtm1Hssh/Cacna1dtm1Hssh
involves: 129S4/SvJae * C57BL/6J
MGI:88293  MP:0009114 decreased pancreatic beta cell mass PMID: 11581302 
Cacna1dtm1Hssh Cacna1dtm1Hssh/Cacna1dtm1Hssh
involves: 129S4/SvJae * C57BL/6J
MGI:88293  MP:0003339 decreased pancreatic beta cell number PMID: 11581302 
Cacna1dtm1Hssh Cacna1dtm1Hssh/Cacna1dtm1Hssh
involves: 129S4/SvJae * C57BL/6J
MGI:88293  MP:0009168 decreased pancreatic islet number PMID: 11581302 
Cacna1dtm1Hssh Cacna1dtm1Hssh/Cacna1dtm1Hssh
involves: 129S4/SvJae * C57BL/6J
MGI:88293  MP:0005293 impaired glucose tolerance PMID: 11581302 
Cacna1dtm1Hssh Cacna1dtm1Hssh/Cacna1dtm1Hssh
involves: 129S4/SvJae * C57BL/6J
MGI:88293  MP:0002891 increased insulin sensitivity PMID: 11581302 
Cacna1dtm1Hssh Cacna1dtm1Hssh/Cacna1dtm1Hssh
involves: 129S4/SvJae * C57BL/6J
MGI:88293  MP:0009176 increased pancreatic alpha cell number PMID: 11581302 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
involves: 129S7/SvEvBrd * C57BL/6J
MGI:88293  MP:0003896 prolonged PR interval PMID: 10929716 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
involves: 129S7/SvEvBrd * C57BL/6J
MGI:88293  MP:0010506 prolonged RR interval PMID: 10929716 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
involves: 129S7/SvEvBrd * C57BL/6J
MGI:88293  MP:0004740 sensorineural hearing loss PMID: 10929716 
Cacna1dtm1Jst Cacna1dtm1Jst/Cacna1dtm1Jst
B6.129S7-Cacna1d
MGI:88293  MP:0004740 sensorineural hearing loss PMID: 12684182 
Clinically-Relevant Mutations and Pathophysiology
Disease:  Aldosterone-producing adenoma
Orphanet: ORPHA85142
Role: 
References:  1,49
Click column headers to sort
Type Species Amino acid change Nucleotide change Description Reference
Missense Human V259D 1,49
Missense Human G403D exon 8B 1,49
Missense Human G403R exon 8B 1,49
Missense Human G403R exon 8A 1,49
Missense Human F747L 1,49
Missense Human I750M 1,49
Missense Human R990H 1,49
Missense Human P1336R 1,49
Missense Human M1354I 1,49
Disease:  Autism
Synonyms: Autism spectrum disorder [Disease Ontology: DOID:0060041]
Disease Ontology: DOID:0060041
OMIM: 209850
Orphanet: ORPHA106
Role: 
References:  38
Click column headers to sort
Type Species Amino acid change Nucleotide change Description Reference
Missense Human A769G 38
Disease:  Congenital hyperaldosteronism
Role: 
Click column headers to sort
Type Species Amino acid change Nucleotide change Description Reference
Missense Human G403D exon 8B 49
Missense Human I750M Gain of function 49
Disease:  Primary aldosteronism, seizures, and neurologic abnormalities
Synonyms: Aldosterone-producing adenoma with seizures and neurological abnormalities [Orphanet: ORPHA369929]
OMIM: 615474
Orphanet: ORPHA369929
Disease:  Sinoatrial node dysfunction and deafness; SANDD
OMIM: 614896
Orphanet: ORPHA324321
Role: 
References:  3,44
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Type Species Amino acid change Nucleotide change Description Reference
Insertion Human c.1208_1209insGGG (in frame glycine insertion in IS6) 3
Clinically-Relevant Mutations and Pathophysiology Comments
Gain of function is shown for several of the mutations associated with aldosterone-producing adrenal adenomas.
Biologically Significant Variants
Type:  Splice variant
Species:  Human
Description:  Short C-terminal tail (does not contain C-terminal modulatory domain which affects channel gating). RNA sequence: EU363339 but with short exon 43 (Cav1.343S) or alternative exon 42A (Cav1.342A); this has the pharmacological effect of lowering sensitivity to dihydropyridine calcium channel blockers.
References:  4,23

References

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How to cite this page

William A. Catterall, Edward Perez-Reyes, Terrance P. Snutch, Joerg Striessnig.
Voltage-gated calcium channels: Cav1.3. Last modified on 13/09/2018. Accessed on 21/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=530.