SLC18 family of vesicular amine transporters

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The vesicular amine transporters (VATs) are putative 12 TM domain proteins that function to transport singly positively charged amine neurotransmitters and hormones from the cytoplasm and concentrate them within secretory vesicles. They function as amine/proton antiporters driven by secondary active transport utilizing the proton gradient established by a multi-subunit vacuolar ATPase that acidifies secretory vesicles (reviewed by [4]). The vesicular acetylcholine transporter (VAChT; [8]) localizes to cholinergic neurons, but non-neuronal expression has also been claimed [11]. Vesicular monoamine transporter 1 (VMAT1, [6]) is mainly expressed in peripheral neuroendocrine cells, but most likely not in the CNS, whereas VMAT2 [7] distributes between both central and peripheral sympathetic monoaminergic neurones [5].

Transporters

VMAT1 (Vesicular monoamine transporter 1 / SLC18A1) Show summary »

VMAT2 (Vesicular monoamine transporter 2 / SLC18A2) Show summary » More detailed page

VAChT (Vesicular acetylcholine transporter / SLC18A3) Show summary »

solute carrier family 18 member B1 / SLC18B1 Show summary »

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How to cite this family page

Database page citation:

SLC18 family of vesicular amine transporters. Accessed on 23/03/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=193.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol. 172: 6110-6202.