Type V RTKs: FGF (fibroblast growth factor) receptor family

Formerly known as: FGF (fibroblast growth factor) receptor family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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Fibroblast growth factor (FGF) family receptors act as homo- and heterodimers, and are characterized by Ig-like loops in the extracellular domain, in which disulphide bridges may form across protein partners to allow the formation of covalent dimers which may be constitutively active. FGF receptors have been implicated in achondroplasia, angiogenesis and numerous congenital disorders. At least 22 members of the FGF gene family have been identified in the human genome [11]. Within this group, subfamilies of FGF may be divided into canonical, intracellular and hormone-like FGFs. FGF1-FGF10 have been identified to act through FGF receptors, while FGF11-14 appear to signal through intracellular targets. Other family members are less well characterized [5].

Receptors

FGFR1 (fibroblast growth factor receptor 1) Show summary » More detailed page

FGFR2 (fibroblast growth factor receptor 2) Show summary » More detailed page

FGFR3 (fibroblast growth factor receptor 3) Show summary » More detailed page

FGFR4 (fibroblast growth factor receptor 4) Show summary » More detailed page

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How to cite this family page

Database page citation:

Type V RTKs: FGF (fibroblast growth factor) receptor family. Accessed on 22/11/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=323.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: Catalytic Receptors. Br J Pharmacol. 170: 1676–1705.