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Receptor Guanylyl Cyclase (RGC) family C
Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Overview
The mammalian genome encodes seven transmembrane guanylyl cyclases, GC-A to GC-G, that are homodimeric receptors activated by a diverse range of endogenous ligands. These enzymes also convert guanosine-5'-triphosphate to the intracellular second messenger cyclic guanosine-3',5'-monophosphate (cyclic GMP).
Receptors
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GC-A (Guanylyl cyclase-A)
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GC-B (Guanylyl cyclase-B)
C
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GC-C (Guanylyl cyclase-C)
C
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GC-D (Guanylyl cyclase-D)
C
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GC-E (Guanylyl cyclase-E)
C
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GC-F (Guanylyl cyclase-F)
C
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GC-G (Guanylyl cyclase-G)
C
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References
1. Bach T, Bergholtz S, Riise J, Qvigstad E, Skomedal T, Osnes JB, Levy FO. (2014) Identification of small molecule NPR-B antagonists by high throughput screening--potential use in heart failure. Naunyn Schmiedebergs Arch. Pharmacol., 387 (1): 5-14. [PMID:24297249]
2. Busby RW, Bryant AP, Bartolini WP, Cordero EA, Hannig G, Kessler MM, Mahajan-Miklos S, Pierce CM, Solinga RM, Sun LJ et al.. (2010) Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit. Eur. J. Pharmacol., 649 (1-3): 328-35. [PMID:20863829]
3. Delporte C, Poloczek P, Gossen D, Tastenoy M, Winand J, Christophe J. (1991) Characterization and regulation of atrial natriuretic peptide (ANP)-R1 receptors in the human neuroblastoma cell line NB-OK-1. Eur. J. Pharmacol., 207 (1): 81-8. [PMID:1680722]
4. Deschênes J, Duperé C, McNicoll N, L'Heureux N, Auger F, Fournier A, De Léan A. (2005) Development of a selective peptide antagonist for the human natriuretic peptide receptor-B. Peptides, 26 (3): 517-24. [PMID:15652659]
5. Edelson JD, Makhlina M, Silvester KR, Vengurlekar SS, Chen X, Zhang J, Koziol-White CJ, Cooper PR, Hallam TJ, Hay DW et al.. (2013) In vitro and in vivo pharmacological profile of PL-3994, a novel cyclic peptide (Hept-cyclo(Cys-His-Phe-d-Ala-Gly-Arg-d-Nle-Asp-Arg-Ile-Ser-Cys)-Tyr-[Arg mimetic]-NH(2)) natriuretic peptide receptor-A agonist that is resistant to neutral endopeptidase and acts as a bronchodilator. Pulm Pharmacol Ther, 26 (2): 229-38. [PMID:23154072]
6. Hamra FK, Eber SL, Chin DT, Currie MG, Forte LR. (1997) Regulation of intestinal uroguanylin/guanylin receptor-mediated responses by mucosal acidity. Proc. Natl. Acad. Sci. U.S.A., 94 (6): 2705-10. [PMID:9122260]
7. Harris LA, Crowell MD. (2007) Linaclotide, a new direction in the treatment of irritable bowel syndrome and chronic constipation. Curr. Opin. Mol. Ther., 9 (4): 403-10. [PMID:17694454]
8. Kambayashi Y, Nakajima S, Ueda M, Inouye K. (1989) A dicarba analog of beta-atrial natriuretic peptide (beta-ANP) inhibits guanosine 3',5'-cyclic monophosphate production induced by alpha-ANP in cultured rat vascular smooth muscle cells. FEBS Lett., 248 (1-2): 28-34. [PMID:2542088]
9. Lorget F, Kaci N, Peng J, Benoist-Lasselin C, Mugniery E, Oppeneer T, Wendt DJ, Bell SM, Bullens S, Bunting S et al.. (2012) Evaluation of the therapeutic potential of a CNP analog in a Fgfr3 mouse model recapitulating achondroplasia. Am. J. Hum. Genet., 91 (6): 1108-14. [PMID:23200862]
10. Martin FL, Sangaralingham SJ, Huntley BK, McKie PM, Ichiki T, Chen HH, Korinek J, Harders GE, Burnett Jr JC. (2012) CD-NP: a novel engineered dual guanylyl cyclase activator with anti-fibrotic actions in the heart. PLoS ONE, 7 (12): e52422. [PMID:23272242]
11. Morishita Y, Sano T, Ando K, Saitoh Y, Kase H, Yamada K, Matsuda Y. (1991) Microbial polysaccharide, HS-142-1, competitively and selectively inhibits ANP binding to its guanylyl cyclase-containing receptor. Biochem. Biophys. Res. Commun., 176 (3): 949-57. [PMID:1674870]
12. Olson LJ, Lowe DG, Drewett JG. (1996) Novel natriuretic peptide receptor/guanylyl cyclase A-selective agonist inhibits angiotensin II- and forskolin-evoked aldosterone synthesis in a human zona glomerulosa cell line. Mol. Pharmacol., 50 (2): 430-5. [PMID:8700153]
13. Shailubhai K, Comiskey S, Foss JA, Feng R, Barrow L, Comer GM, Jacob GS. (2013) Plecanatide, an oral guanylate cyclase C agonist acting locally in the gastrointestinal tract, is safe and well-tolerated in single doses. Dig. Dis. Sci., 58 (9): 2580-6. [PMID:23625291]
14. Singh G, Kuc RE, Maguire JJ, Fidock M, Davenport AP. (2006) Novel snake venom ligand dendroaspis natriuretic peptide is selective for natriuretic peptide receptor-A in human heart: downregulation of natriuretic peptide receptor-A in heart failure. Circ. Res., 99 (2): 183-90. [PMID:16778132]
15. Suga S, Nakao K, Hosoda K, Mukoyama M, Ogawa Y, Shirakami G, Arai H, Saito Y, Kambayashi Y, Inouye K. (1992) Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Endocrinology, 130 (1): 229-39. [PMID:1309330]
16. Weber W, Fischli W, Hochuli E, Kupfer E, Weibel EK. (1991) Anantin--a peptide antagonist of the atrial natriuretic factor (ANF). I. Producing organism, fermentation, isolation and biological activity. J. Antibiot., 44 (2): 164-71. [PMID:1849131]
17. Wyss DF, Lahm HW, Manneberg M, Labhardt AM. (1991) Anantin--a peptide antagonist of the atrial natriuretic factor (ANF). II. Determination of the primary sequence by NMR on the basis of proton assignments. J. Antibiot., 44 (2): 172-80. [PMID:1826288]
NC-IUPHAR subcommittee and family contributors
Subcommittee members:
Adrian Hobbs (Co-chairperson)
Scott Waldman (Co-chairperson)
John C. Burnett, Jr.
John Garthwaite
Doris Koesling
Michaela Kuhn
Lincoln Potter
Harald Schmidt |
Other contributors:
Annie Beuve
Peter Brouckaert
Andreas Friebe |
How to cite this family page
Database page citation:
Adrian Hobbs, Scott Waldman, Annie Beuve, Peter Brouckaert, John C. Burnett, Andreas Friebe, John Garthwaite, Doris Koesling, Michaela Kuhn, Lincoln Potter, Harald Schmidt. Receptor Guanylyl Cyclase (RGC) family. Accessed on 12/07/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=662.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors. Br J Pharmacol. 172: 5979-6023.
