GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

trastuzumab   Click here for help

GtoPdb Ligand ID: 5082

Synonyms: D5v8 | Herceptin® | R-597
Approved drug
trastuzumab is an approved drug (FDA (1998), EMA (2000))
Compound class: Antibody
Comment: Trastuzumab is a humanized IgG1κ monoclonal antibody targeting HER2.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.

Biosimilars:
NameTrade nameCompanyClinical PhaseIndications
trastuzumab-dkst; MYL-1401OHertraz; Canmab; OgivriMylan and Biocon Approved in India, FDA 2017, EMA 2018 (Ogivri)Breast cancer
trastuzumab-pkrb; CT-P6Herzuma; CredimaCelltrionApproved in S Korea, EMA & FDA 2018Breast cancer
trastuzumab-dttb; SB3OntruzantSamsung BioepisApproved (EMA 2017, FDA 2019)All approved indications of the reference product
trastuzumab-beta; trastuzumab-anns; ABP-980 [3]KanjintiAmgen/AllerganApproved (EMA 2018, FDA 2019)All approved indications of the reference product
trastuzumab-qyyp; PF-05280014TrazimeraPfizerApproved (FDA 2019; see REFLECTIONS B327-02 trial NCT01989676)All approved indications of the reference product
trastuzumab-strf; HLX02Zercepac; HercessiShanghai Henlius Biotech; Accord HealthcareApproved (EMA 2020, FDA 2024)EMA approved to treat HER2 positive metastatic breast cancer; FDA approval indicated for breast cancer plus HER2-overexpressing gastric or gastroesophageal junction adenocarcinomas
trastuzumab; EG12014HerwendaSandozApproved (EMA 2023)Early breast cancer and metastatic gastric cancer
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: trastuzumab

Classification Click here for help
Compound class Antibody
Approved drug? Yes. US FDA (1998)  |  EU EMA (2000)
WHO Essential Medicine WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
International Nonproprietary Names Click here for help
INN number INN
7637 trastuzumab
Synonyms Click here for help
D5v8 | Herceptin® | R-597
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 97
Reactome Drug Reactome logo R-ALL-9634466
Reactome Reaction Reactome logo R-HSA-9665405, R-HSA-9649393, R-HSA-9652277, R-HSA-9665232, R-HSA-9665696
Other databases
GtoPdb PubChem SID 178101775
PubChem SID 178101775
Search PubMed clinical trials trastuzumab
Search PubMed titles trastuzumab
Search PubMed titles/abstracts trastuzumab
Wikipedia Trastuzumab