Ligand id: 5082

Name: trastuzumab

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View more information in the IUPHAR Pharmacology Education Project: trastuzumab

Bioactivity Comments
The use of anti-HER2 monoclonals is covered by patent WO1989006692, in which the clone that produced trastuzumab is 4D5 [1]. Efficacy of the resultant monoclonals was assessed in vitro (for example ELISA for antigen binding and in vitro cellular assays for anti-tumour activity) but no affinity value for the interaction between the antibody and its antigen are provided in the patent.
Selectivity at catalytic receptors
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Target Sp. Type Action Affinity Units Concentration range (M) Reference
erb-b2 receptor tyrosine kinase 2 Hs Antibody Inhibition - - -
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