Type I RTKs: ErbB (epidermal growth factor) receptor family

Formerly known as: ErbB (epidermal growth factor) receptor family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).


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ErbB family receptors are Class I receptor tyrosine kinases [9]. ERBB2 (also known as HER-2 or NEU) appears to act as an essential partner for the other members of the family without itself being activated by a cognate ligand [10]. Ligands of the ErbB family of receptors are peptides, many of which are generated by proteolytic cleavage of cell-surface proteins. HER/ErbB is the viral counterpart to the receptor tyrosine kinase EGFR. All family members heterodimerize with each other to activate downstream signalling pathways and are aberrantly expressed in many cancers, particularly forms of breast cancer and lung cancer. Mutations in the EGFR are responsible for acquired resistance to tyrosine kinase inhibitor chemotherapeutics.


EGFR (epidermal growth factor receptor) Show summary » More detailed page

HER2 (erb-b2 receptor tyrosine kinase 2) Show summary » More detailed page

HER3 (erb-b2 receptor tyrosine kinase 3) Show summary » More detailed page

HER4 (erb-b2 receptor tyrosine kinase 4) Show summary » More detailed page


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How to cite this family page

Database page citation:

Type I RTKs: ErbB (epidermal growth factor) receptor family. Accessed on 22/10/2016. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=320.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors. Br J Pharmacol. 172: 5979-6023.