Ligand id: 5082

Name: trastuzumab

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Summary of Clinical Use
Used in the management of HER2 overexpressing breast cancer.
Mechanism Of Action and Pharmacodynamic Effects
Trastuzumab binds to the cell surface HER2 epidermal growth factor receptor, expression of which is dysregulated in many breast cancer cells. By binidng to HER2, trastuzumab blocks the HER2 pathway and causes cell cycle arrest during the G1 phase, thereby inhibiting the replication of cancer cells.
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