bromocriptine

Ligand id: 35

Name: bromocriptine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 10
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 118.21
Molecular weight 653.22
XLogP 3.49
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
5-HT1D receptor Hs Agonist Partial agonist 8.0 pKi - 4
pKi 8.0 [4]
α2A-adrenoceptor Hs Antagonist Antagonist 8.0 pKi - 4
pKi 8.0 [4]
5-HT1A receptor Hs Agonist Partial agonist 7.9 pKi - 4
pKi 7.9 [4]
D2 receptor Hs Agonist Full agonist 7.3 – 8.3 pKi - 2,4-5
pKi 7.3 – 8.3 [2,4-5]
5-HT7 receptor Rn Agonist Full agonist 7.3 – 8.0 pKi - 6
pKi 7.3 – 8.0 [6]
D3 receptor Hs Agonist Partial agonist 7.1 – 8.2 pKi - 2,4-5
pKi 7.1 – 8.2 [2,4-5]
α2C-adrenoceptor Hs Antagonist Antagonist 7.6 pKi - 4
pKi 7.6 [4]
5-HT6 receptor Hs Agonist Full agonist 7.5 pKi - 3
pKi 7.5 [3]
5-HT6 receptor Rn Agonist Partial agonist 7.5 pKi - 1
pKi 7.5 [1]
α2B-adrenoceptor Hs Antagonist Antagonist 7.5 pKi - 4
pKi 7.5 [4]
5-HT2B receptor Hs Antagonist Antagonist 7.3 pKi - 4
pKi 7.3 [4]
D2 receptor Rn Agonist Partial agonist 7.3 pKi - 7
pKi 7.3 [7]
D3 receptor Rn Agonist Full agonist 7.1 pKi - 7
pKi 7.1 [7]
5-HT2A receptor Hs Agonist Partial agonist 7.0 pKi - 4
pKi 7.0 [4]
5-HT1B receptor Hs Agonist Partial agonist 6.5 pKi - 4
pKi 6.5 [4]
D4 receptor Hs Antagonist Antagonist 6.4 pKi - 4
pKi 6.4 [4]
D5 receptor Hs Agonist Full agonist 6.3 pKi - 4,8
pKi 6.3 [4,8]
D1 receptor Hs Agonist Partial agonist 6.2 pKi - 4,8
pKi 6.2 [4,8]
5-HT2C receptor Hs Agonist Partial agonist 6.1 pKi - 4
pKi 6.1 [4]