ethylisopropylamiloride

Ligand id: 4186

Name: ethylisopropylamiloride

Abbreviated name: EIPA

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 136.51
Molecular weight 299.13
XLogP 0.76
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
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Target Type Action Affinity Units Concentration range (M) Reference
α2A-adrenoceptor Allosteric modulator Positive 1.8 pKd - 1
pKd 1.8 [1]
Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TRPP2 Channel blocker - 5.0 pIC50 -
pIC50 5.0 (IC50 1.05x10-5 M)
ASIC1 Channel blocker - 5.0 pIC50 -
pIC50 5.0 (IC50 1x10-5 M) ASIC1a
Ligand mentioned in the following text fields