lisuride

Ligand id: 43

Name: lisuride

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 51.37
Molecular weight 338.21
XLogP 2.24
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at GPCRs
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
α2A-adrenoceptor Hs Antagonist Antagonist 10.3 pKi - 7
pKi 10.3 [7]
α2B-adrenoceptor Hs Antagonist Antagonist 9.9 pKi - 7
pKi 9.9 [7]
α2C-adrenoceptor Hs Antagonist Antagonist 9.9 pKi - 7
pKi 9.9 [7]
5-HT1A receptor Hs Agonist Full agonist 9.7 – 9.8 pKi - 7,9-10
pKi 9.7 – 9.8 [7,9-10]
D3 receptor Hs Agonist Partial agonist 9.6 pKi - 7
pKi 9.6 [7]
D2 receptor Hs Agonist Partial agonist 9.2 – 9.5 pKi - 7
pKi 9.2 – 9.5 [7]
5-HT1D receptor Hs Agonist Partial agonist 9.0 pKi - 7
pKi 9.0 [7]
5-HT2B receptor Hs Antagonist Antagonist 8.9 pKi - 7
pKi 8.9 [7]
5-HT7 receptor Rn Agonist Full agonist 8.2 – 9.3 pKi - 11-12
pKi 8.2 – 9.3 [11-12]
5-HT2A receptor Hs Agonist Partial agonist 8.6 pKi - 7
pKi 8.6 [7]
D5 receptor Hs Agonist Partial agonist 8.5 pKi - 7
pKi 8.5 [7]
α1A-adrenoceptor Hs Antagonist Antagonist 8.3 pKi - 7
pKi 8.3 [7]
D4 receptor Hs Agonist Partial agonist 8.3 pKi - 7
pKi 8.3 [7]
5-HT2C receptor Hs Agonist Partial agonist 7.9 – 8.3 pKi - 5-7
pKi 7.9 – 8.3 [5-7]
5-HT6 receptor Hs Agonist Partial agonist 8.0 – 8.1 pKi - 2,4
pKi 8.0 – 8.1 [2,4]
5-HT6 receptor Rn Agonist Partial agonist 7.5 – 8.3 pKi - 1,3-4,8
pKi 7.5 – 8.3 [1,3-4,8]
5-HT1B receptor Hs Agonist Partial agonist 7.7 pKi - 7
pKi 7.7 [7]
D1 receptor Hs Agonist Partial agonist 7.2 pKi - 7
pKi 7.2 [7]