propofol

Ligand id: 5464

Name: propofol

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 0
Hydrogen bond donors 1
Rotatable bonds 2
Topological polar surface area 20.23
Molecular weight 178.14
XLogP 4.42
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
As the GABAA binding site was reported to exist on both β3 homopentamers and α1β3 heteropentamers [3] we have not tagged a primary drug target for propofol.
Selectivity at ion channels
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Target Sp. Type Action Affinity Units Concentration range (M) Reference
HCN1 Mm Channel blocker - 5.2 pIC50 - 1-2
pIC50 5.2 [1-2]
Voltage: -40.0 mV
Ligand mentioned in the following text fields