Synonyms: Ativan® | Orfidal®
lorazepam is an approved drug (FDA (1977))
Compound class:
Synthetic organic
Comment: Lorazepam is used for the short-term management of severe anxiety. where it is thought to have a high affinity for GABA receptors. In March of 2016 it has also been reported as a GPR68 surrogate allosteric ligand [1].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖View more information in the IUPHAR Pharmacology Education Project: lorazepam |
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Bioactivity Comments |
Due to the complex and varied nature of the precise subunit composition of GABAA receptors, and a paucity of affinity data with definitive molecular details, we have not tagged a primary target for this drug. In March 2016 lorazepam was reported as a GPR68 positive allosteric modulator for the agonist proton for cAMP production. |
Selectivity at GPCRs | |||||||||||||||||||||||||||||||||||||||||||||||||||||||
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