lorazepam

Ligand id: 5884

Name: lorazepam

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 61.69
Molecular weight 320.01
XLogP 3.88
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Due to the complex and varied nature of the precise subunit composition of GABAA receptors, and a paucity of affinity data with definitive molecular details, we have not tagged a primary target for this drug. In March 2016 lorazepam was reported as a GPR68 positive allosteric modulator for the agonist proton for cAMP production.
Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
GPR68 Allosteric modulator Positive - - - 1
lorazepam characterised as a non-selective GPR68 positive allosteric modulator for the agonist proton in cAMP production [1]
Selectivity at rat GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
α1B-adrenoceptor Allosteric modulator Positive 3.8 pKi - 2
pKi 3.8 (Ki 1.7x10-4 M) [2]