Ligand id: 5884

Name: lorazepam

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 1
Topological polar surface area 61.69
Molecular weight 320.01
XLogP 3.88
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Huang XP, Karpiak J, Kroeze WK, Zhu H, Chen X, Moy SS, Saddoris KA, Nikolova VD, Farrell MS, Wang S et al.. (2015)
Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65.
Nature, 527 (7579): 477-83. [PMID:26550826]
2. Waugh DJ, Gaivin RJ, Damron DS, Murray PA, Perez DM. (1999)
Binding, partial agonism, and potentiation of alpha(1)-adrenergic receptor function by benzodiazepines: A potential site of allosteric modulation.
Journal of Pharmacology & Experimental Therapeutics, 291: 1164-1171. [PMID:10565838]