tacrine

Ligand id: 6687

Name: tacrine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 38.91
Molecular weight 198.12
XLogP 3.19
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Dual inhibitor of butyrylcholine esterase (P06276) and acetylcholinesterase (P22303).
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
acetylcholinesterase (Cartwright blood group) Inhibitor Inhibition 7.5 pKi - 1
pKi 7.5 (Ki 3x10-8 M) [1]
butyrylcholinesterase Inhibitor Inhibition 7.2 pKi - 1
pKi 7.2 (Ki 7x10-8 M) [1]
Selectivity at mouse GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
M1 receptor Allosteric modulator Negative 5.7 pIC50 - 2
pIC50 5.7 (IC50 2x10-6 M) [2]
M2 receptor Allosteric modulator Negative 5.7 pIC50 - 2
pIC50 5.7 (IC50 2.1x10-6 M) [2]