Ligand id: 7343

Name: evolocumab

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
Pending publication, affinity data for evolocumab is derived from patent US8030457.
Selectivity at human enzymes
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
proprotein convertase subtilisin/kexin type 9 Inhibitor Inhibition 9.7 pKd - 3
pKd 9.7 (Kd 1.9x10-10 M) [3]
Description: Dissociation equilibrium constant for wild-type hPCSK9, measured using proprietary BIACore® technology.
Ligand mentioned in the following text fields