Ligand id: 7343

Name: evolocumab

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
Pending publication, affinity data for evolocumab is derived from patent US8030457.
Selectivity at enzymes
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Target Sp. Type Action Affinity Units Concentration range (M) Reference
proprotein convertase subtilisin/kexin type 9 Hs Inhibitor Inhibition 9.7 pKd - 3
pKd 9.7 (Kd 1.9x10-10 M) [3]
Description: Dissociation equilibrium constant for wild-type hPCSK9, measured using proprietary BIACore® technology.
Ligand mentioned in the following text fields