AT-9283

Ligand id: 7949

Name: AT-9283

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 4
Rotatable bonds 6
Topological polar surface area 102.38
Molecular weight 381.19
XLogP -0.4
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
3nM AT-9283 inhibits Aurora A activity by 52% and Aurora B activity by 58% [1]. In the same study AT-9283 inhibited the activity of ABLT315I mutant with an IC50 of 4nM.
Selectivity at enzymes
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Janus kinase 3 Hs Inhibitor Inhibition 9.0 pIC50 - 1
pIC50 9.0 (IC50 1.1x10-9 M) [1]
Janus kinase 2 Hs Inhibitor Inhibition 8.9 pIC50 - 1
pIC50 8.9 (IC50 1.2x10-9 M) [1]
aurora kinase A Hs Inhibitor Inhibition ~8.5 pIC50 - 1
pIC50 ~8.5 (IC50 ~3x10-9 M) [1]
aurora kinase B Hs Inhibitor Inhibition ~8.5 pIC50 - 1
pIC50 ~8.5 (IC50 ~3x10-9 M) [1]
serine/threonine kinase 17a Hs Inhibitor Inhibition 8.0 pIC50 - 1
pIC50 8.0 (IC50 1x10-8 M) [1]
ribosomal protein S6 kinase A6 Hs Inhibitor Inhibition 7.5 – 8.0 pIC50 - 1
pIC50 7.5 – 8.0 (IC50 3x10-8 – 1x10-8 M) [1]