Ligand id: 8455

Name: daprodustat

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 2
Rotatable bonds 6
Topological polar surface area 124.09
Molecular weight 393.19
XLogP 1.68
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Bioactivity Comments
We have been unable to find an ihibitory constant for daprodustat's inhibition of HIF-PHs (EGLN1-3). Associated patents examine stabilisation of HIF-1α or increased erythropoietin levels as markers of HIF-PH inhibition.