Ligand id: 9325

Name: AZD7594

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 112.94
Molecular weight 606.23
XLogP 4.28
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Bioactivity Comments
The data range in the table maps to the stereoisomers mentioned in the Summary comment for this ligand. There is little difference in affinity between them.
Selectivity at human nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Glucocorticoid receptor Agonist Agonist 9.0 – 9.0 pIC50 - 1
pIC50 9.0 – 9.0 (IC50 1.08x10-9 – 9.1x10-10 M) [1]
Description: Measuring displacement of 3H-dexamethasone from the human GR in a competition radioligand binding assay.