Ligand id: 9325

Name: AZD7594

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 112.94
Molecular weight 606.23
XLogP 4.28
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Bioactivity Comments
AZD7594 transrepresses transctiption of GR-induced genes with an IC50 of 55nM [2].
Selectivity at nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Glucocorticoid receptor Hs Agonist Agonist 9.1 pEC50 - 1-2
pEC50 9.1 (EC50 9x10-10 M) [1-2]
Description: Measuring displacement of 3H-dexamethasone from the human GR in a competition radioligand binding assay.