Ligand id: 9325

Name: AZD7594

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 112.94
Molecular weight 606.23
XLogP 4.28
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

Immunopharmacology Comments
AZD7594 has not effect on other hormone receptors of the 3-Ketosteroid receptor family, or on ERα or ERβ. Its high degree of selectivity is predicted to enhance clinical safety and differentiates this type of selective GR modulator from conventional steroidal medications like budesonide and fluticasone propionate, which are potent activators of the PR and MR (and of the AR in the case of budesonide) in addition to the GR.
Immunopharmacology Disease
Disease X-Refs Comment References
Asthma Disease Ontology: DOID:2841
OMIM: 600807
No progress beyond Phase 2 trial.