Ligand id: 9325

Name: AZD7594

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 112.94
Molecular weight 606.23
XLogP 4.28
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

1. Berger M, Rehwinkel H, Dahmen J, Eriksson A, Hansson T, Hossain N, Klingstedt PT, Lepisto M, Nilsson S, Memmerling M et al.. (2014)
Phenyl and benzodioxinyl substituted indazoles derivatives.
Patent number: US8916600. Assignee: Astrazeneca Ab, Bayer Pharma Aktiengesellschaft. Priority date: 20/05/2008. Publication date: 23/12/2014.
2. Hemmerling M, Nilsson S, Edman K, Eirefelt S, Russell W, Hendrickx R, Johnsson E, Kärrman Mårdh C, Berger M, Rehwinkel H et al.. (2017)
Selective Nonsteroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases.
J. Med. Chem., 60 (20): 8591-8605. [PMID:28937774]