CC-220

Ligand id: 9618

Name: CC-220

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 88.18
Molecular weight 449.2
XLogP 1.54
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Bioactivity Comments
CC-220 binds cereblon (CRBN) with higher affinity than lenalidomide or pomalidomide [3]. CC-220 displaces a Cy5-conjugated cereblon modulating compound from the binding pocket of CRBN with an IC50 of 60nM.