asenapine

Ligand id: 22

Name: asenapine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 12.47
Molecular weight 285.09
XLogP 4.27
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Asenapine is used to treat the symptoms of psychotic conditions such as schizophrenia and bipolar disorder (manic depression) in adults.
Mechanism Of Action and Pharmacodynamic Effects
Although asenapine has affinity for many neuronal receptors [6], the principal MMOA is believed to arise from antagonism of the dopamine D2 and serotonin 5-HT2A and 5-HT2C receptors. Antagonism of these two serotonin receptor subtypes appears to be involved in the allevation of negative symptoms of schizophrenia [1-2,4]. The dopamine D2 receptor is also implicated in schizophrenia. This multireceptor mechanism helps to normalise the activity of the brain, reducing manic symptoms.
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