asenapine

Ligand id: 22

Name: asenapine

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 12.47
Molecular weight 285.09
XLogP 4.27
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Lieberman JA, Mailman RB, Duncan G, Sikich L, Chakos M, Nichols DE, Kraus JE. (1998)
Serotonergic basis of antipsychotic drug effects in schizophrenia.
Biol. Psychiatry44 (11): 1099-117. [PMID:9836014]
2. Meltzer HY, Li Z, Kaneda Y, Ichikawa J. (2003)
Serotonin receptors: their key role in drugs to treat schizophrenia.
Prog. Neuropsychopharmacol. Biol. Psychiatry27 (7): 1159-72. [PMID:14642974]
3. Newman-Tancredi A, Gavaudan S, Conte C, Chaput C, Touzard M, Verriele L, Audinot V, Millan MJ. (1998)
Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study.
Eur J Pharmacol355: 245-256. [PMID:9760039]
4. Reynolds GP, Yao Z, Zhang X, Sun J, Zhang Z. (2005)
Pharmacogenetics of treatment in first-episode schizophrenia: D3 and 5-HT2C receptor polymorphisms separately associate with positive and negative symptom response.
Eur Neuropsychopharmacol15 (2): 143-51. [PMID:15695058]
5. Schotte A, Janssen PF, Gommeren W, Luyten WH, Van Gompel P, Lesage AS, De Loore K, Leysen JE. (1996)
Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding.
Psychopharmacology (Berl)124: 57-73. [PMID:8935801]
6. Shahid M, Walker GB, Zorn SH, Wong EH. (2009)
Asenapine: a novel psychopharmacologic agent with a unique human receptor signature.
J. Psychopharmacol. (Oxford)23 (1): 65-73. [PMID:18308814]