asenapine

Ligand id: 22

Name: asenapine

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: asenapine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 0
Topological polar surface area 12.47
Molecular weight 285.09
XLogP 4.27
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human GPCRs
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
5-HT2A receptor Antagonist Antagonist 10.2 pKi - 6
pKi 10.2 (Ki 6x10-11 M) [6]
H1 receptor Antagonist Antagonist 9.8 pKi - 5
pKi 9.8 [5]
D2 receptor Antagonist Antagonist 8.9 pKi - 6
pKi 8.9 (Ki 1.2x10-9 M) [6]
5-HT1D receptor Agonist Full agonist 8.4 pKi - 5
pKi 8.4 [5]
5-HT1A receptor Agonist Full agonist 8.0 – 8.3 pKi - 3,5
pKi 8.0 – 8.3 [3,5]
5-HT1B receptor Agonist Full agonist 8.1 pKi - 5
pKi 8.1 [5]
5-ht1e receptor Agonist Full agonist 8.0 pKi - 5
pKi 8.0 [5]