Ligand id: 2342

Name: quinidine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 45.59
Molecular weight 324.18
XLogP 2.66
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Quinidine is an antimalarial schizonticide but is also used in the treatment of ventricular pre-excitation and cardiac dysrhythmias.
Mechanism Of Action and Pharmacodynamic Effects
Quinidine blocks sodium channels in the neuronal cell membrane, which limits the spread of seizure activity and reduces seizure propagation. The antiarrhythmic actions of quinidine are mediated through its action on sodium channels in Purkinje fibres. Quinidine also seems to act on other channels including inwardly rectifying potassium channels. However, we have been unable to find affinity data for this drug (at the human targets) to substantiate this MMOA.
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