Ligand id: 2342

Name: quinidine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 45.59
Molecular weight 324.18
XLogP 2.66
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

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Characterisation of the human voltage-gated potassium channel gene, KCNA7, a candidate gene for inherited cardiac disorders, and its exclusion as cause of progressive familial heart block I (PFHBI).
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Slick (Slo2.1), a rapidly-gating sodium-activated potassium channel inhibited by ATP.
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Effects of flecainide and quinidine on Kv4.2 currents: voltage dependence and role of S6 valines.
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Interaction of organic cations with a newly identified plasma membrane monoamine transporter.
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Molecular determinants for high-affinity block of human EAG potassium channels by antiarrhythmic agents.
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Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels.
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Characterization of four types of background potassium channels in rat cerebellar granule neurons.
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Class I antiarrhythmic drug receptor: biochemical evidence for state-dependent interaction with quinidine and lidocaine.
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Single-channel properties and pH sensitivity of two-pore domain K+ channels of the TALK family.
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KCNT1 gain of function in 2 epilepsy phenotypes is reversed by quinidine.
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TWIK-2, an inactivating 2P domain K+ channel.
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Functional distinction of human EAG1 and EAG2 potassium channels.
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Class I antiarrhythmic drugs: allosteric inhibitors of [3H] batrachotoxinin binding to rat cardiac sodium channels.
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Time-, voltage-, and state-dependent block by quinidine of a cloned human cardiac potassium channel.
Mol. Pharmacol., 41 (2): 322-30. [PMID:1538710]
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Pharmacology of hSlo3 channels and their contribution in the capacitation-associated hyperpolarization of human sperm.
Biochem. Biophys. Res. Commun., 466 (3): 554-9. [PMID:26381170]
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Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine.
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Substrate specificity of MATE1 and MATE2-K, human multidrug and toxin extrusions/H(+)-organic cation antiporters.
Biochem. Pharmacol., 74 (2): 359-71. [PMID:17509534]
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The plasma membrane monoamine transporter (PMAT): Structure, function, and role in organic cation disposition.
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Mechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and barium.
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Antiarrhythmic and bradycardic drugs inhibit currents of cloned K+ channels, KV1.2 and KV1.4.
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Pharmacological activation and inhibition of Slack (Slo2.2) channels.
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