Ligand id: 2367

Name: colchicine

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: colchicine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 83.09
Molecular weight 399.17
XLogP 1.73
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Primarily used to treat gout.
Mechanism Of Action and Pharmacodynamic Effects
CHEMBL lists tubulin as the target of colchicine inhibition, and data suggests this may play a part in its effectiveness against gout (killing inflammatory leukocytes by disabling microtubule formation). The major antigout mechanism of colchicine is believed to be its ability to inhibit urate crystal deposition and the subsequent inflammatory response that initiates and sustains acute gout episodes.