colchicine

Ligand id: 2367

Name: colchicine

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View more information in the IUPHAR Pharmacology Education Project: colchicine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 83.09
Molecular weight 399.17
XLogP 1.73
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Cifuentes M, Schilling B, Ravindra R, Winter J, Janik ME. (2006)
Synthesis and biological evaluation of B-ring modified colchicine and isocolchicine analogs.
Bioorg. Med. Chem. Lett.16 (10): 2761-4. [PMID:16504507]
2. Machu TK. (1998)
Colchicine competitively antagonizes glycine receptors expressed in Xenopus oocytes.
Neuropharmacology37 (3): 391-6. [PMID:9681937]