Ligand id: 2416

Name: fampridine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 38.91
Molecular weight 94.05
XLogP 0.37
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Approved to improve walking ability in adults with multiple sclerosis (MS) whose walking is impaired [10,15].
Mechanism Of Action and Pharmacodynamic Effects
Fampridine blocks voltage-gated potassium channels on nerve fibres. When these channels are prevented from functioning on MS damaged nerves, potassium ions are retained within the nerve cells and this is believed to facilitate propogation of the electrical impulse along the nerves to the muscles. This improved muscle stimulation then makes walking easier.
External links